Material Properties of Brittle Bones
نویسندگان
چکیده
INTRODUCTION Osteogenesis imperfecta (OI) is a genetic disorder of type I collagen that results in bone fragility. This fragility is believed to stem from a combination of bone mass deficiency and compromised bone material properties [13]. Little data, however, is yet available to describe bone material properties in individuals with OI. This study presents the first characterization of bone material strength and toughness in children with OI.
منابع مشابه
Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse.
UNLABELLED To examine the link between bone material properties and skeletal fragility, we analyzed the mechanical, histological, biochemical, and spectroscopic properties of bones from a murine model of skeletal fragility (SAMP6). Intact bones from SAMP6 mice are weak and brittle compared with SAMR1 controls, a defect attributed to reduced strength of the bone matrix. The matrix weakness is at...
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